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31 March - 2 April 2020 // Nuremberg, Germany

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Exhibitors & Products MedtecLIVE 2019
Zoom product LOGO_PAcrAm™: Multimodal Biofunctional Coating for Diagnostic

PAcrAm™: Multimodal Biofunctional Coating for Diagnostic

LOGO_PAcrAm™: Multimodal Biofunctional Coating for Diagnostic

PAcrAm™: Multimodal Biofunctional Coating for Diagnostic

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The core of this technology is to be found in the functionalizable polymeric backbone that enables different functional and binding groups to be inserted using the same, stable and reproducible coupling scheme. In particular, by appropriately selecting and combining binding groups, it is possible to tune adhesion on selected substrates or to obtain a “universal molecule” that can adhere on many different substrates.

Coating descriptionPAcrAm™ Multimodal Coating

Substrate examples: glass, quartz, silicon wafers, polyolefins (COC and COP), (plasma-activated) polymers, metal oxides (Al2O3, Ta2O5, ITO, TiO2, ZrO2, Fe2O3)

Immobilization mechanism: Binding via a combination of different binding groups (multimodal)

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Key Product Features:

  • Polymers carrying non-bio-functionalized PEG or PMOXA side-chains (methoxy terminated) are used for protection against biofouling, i.e. for the reduction of protein uptake, or providing a cell- and bacteria-resistant coating.
  • Azide-functionalized PEG serves as the basis for further click reactions.
  • Bio-functionalized polymers for use in bio-sensing (Biotin and nitrilotriacetic acid –NTA version) or cell culture (RGD peptide) are in preparation.

Typical applications:

  • Functionalization of sensing-device chips for diagnostics and bio-analytics
  • Blocking of cell adhesion and protein-non-specific signals
  • Non-reactive background for proteomics and cell-culture applications
  • Patterned biochips for controlled uptake of DNA/RNA strains, proteins, or cells
  • Preparation of high-contrast slides for fluorescence measurements
  • Patterning of bio-chips
  • Optimization of the wetting behaviour of microfluidic devices
  • Anti-bacterial, cell-resistant treatment of metallic or ceramic medical devices
  • Improved tissue integration with bioactive coatings, using peptides or growth factors
  • Surfaces with selective biological response to different cell types

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